The emergence of frontier AI models—capable of autonomously discovering zero-day vulnerabilities, generating novel payloads, and executing rapid, multi-stage attack chains—has shifted the cybersecurity landscape from AI-assisted to fully AI-driven threats. Traditional, signature-based security frameworks fail to protect endpoints, which have expanded to include user-deployed AI models, autonomous agents, and Model Context Protocol (MCP) servers. To neutralize these high-speed threats, Palo Alto Networks combines Cortex XDR® and Koi Agentic Endpoint Security into a unified, proactive defense platform. This joint solution addresses modern attack vectors across four critical use cases: AI-accelerated vulnerability exploitation, AI-driven supply chain attacks, autonomous AI agents as attack vectors, and novel fileless payloads.